Pure autonomic failure (PAF), also known as Bradbury–Eggleston syndrome or idiopathic orthostatic hypotension, is a rare disease that causes dizziness and fainting, visual disturbance, and neck pain. It is considered a prodromal stage that often develops later into a CNS synucleinopathy. α-Synuclein aggregation, including formation of Lewy bodies and Lewy neurites, similar to Parkinson’s disease, and GCI, similar to MSA, are a characteristic of PAF, though unlike in the CNS synucleinpathies, they form in the parasympathetic nervous system.