Prostatic amyloidosis is a rare condition in which amyloid is deposited in the prostate and lower genital/urinary tract. The amyloid in this condition tends to have diverse morphology and may be composed of transthyretin, β2-microglobulin, or both proteins. The clinical presentation of prostatic amyloidosis can be part of systemic amyloidosis (primary or secondary) and resemble a tumor of the prostate.