Finnish Hereditary Systemic Amyloidosis

Finnish hereditary systemic amyloidosis (also called familial amyloid polyneuropathy type IV or Meretoja amyloidosis) is a rare disease caused by mutations in the gene that encodes the protein gelsolin. Several hundred cases of the disease have been documented, mostly in Finland, but also in the USA, Denmark, and the Netherlands. The disease causes multiple pathologies, including in the brain, eye, and peripheral nervous system.