Hereditary Renal Amyloidosis

Hereditary renal amyloidosis is a rare form of amyloidosis in which the affected organ is predominantly the kidney. The disease sometimes is called Ostertag Type B. Similarly to hereditary non-neuropathic systemic amyloidosis, hereditary renal amyloidosis can be caused by mutations in different proteins, including cystatin C, the α-chain of the protein fibrinogen A, or gelsolin. The mutant forms of these proteins form abnormal aggregates and deposits in the kidneys.