About
Ibrar Siddique received his Ph.D. in Life Sciences from the National Institute of Immunology, India, in 2018. In his graduate work, he studied the role of small molecules in the prevention and treatment of Alzheimer’s disease in the 5X FAD mouse model. To broaden his horizons, he also investigated the role of an endoplasmic reticulum resident protein (JWA/GTRAP3-18) in the regulation of autophagy in neuronal cells. Currently, in the Bitan laboratory, he is interested in studying the pharmacokinetics of molecular tweezers, developing minimally invasive biomarkers for various neurodegenerative diseases, and exploring mammalian exophers.
Education and Degree(s)
- B.S. - Aligarh Muslim University, Aligarh, India, 2010.
- M.S. - Aligarh Muslim University, Aligarh, India, 2012.
- Ph.D. - National Institute of Immunology, New Delhi, India
Publications
- AJ Mason, I Hurst, R Malik, I Siddique, I Solomonov, I Sagi, F-G Klärner, T Schrader, and G Bitan (2020) Different inhibitors of Aβ42-induced toxicity have distinct metal-ion dependency. ACS Chem. Neurosci. 11: 2243–2255.
- N Bengoa-Vergniory, E Faggiani, P Ramos-Gonzalez, E Kirkiz, N Connor-Robson, LV Brown, I Siddique, Z Li, S Vingill, M Cioroch, F Cavaliere, S Threlfell, B Roberts, T Schrader, F-G Klärner, S Cragg, B Dehay, G Bitan, C Matute, E Bezard and R Wade-Martins (2020) CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and mouse models of Parkinson’s. Nat. Commun. 11: 4885.
- J Di, I Siddique*, Z Li, G Malki, S Hornung, S Dutta, I Hurst, E Ishaaya, A Wang, S Tu, A Boghos, I Ericsson, F-G Klärner, T Schrader, and G Bitan (2021) The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alz. Res. Ther., 13: 6. *Co-first author.
- Z Li, I Siddique, I Hadrović, A Kirupakaran, J. Li, Y. Zhang, F-G Klärner, T Schrader, and G Bitan (2021) Lysine-selective molecular tweezers are cell-penetrant a concentrate in lysosomes. Commun. Biol., 4: 1076.
- JA Palma, J Martinez, P Millar Vernetti, T Ma, MA Perez, J Zhong, Y Qian, S Dutta, KN Maina, I Siddique, G Bitan, B Ades-Aron, TM Shepherd, UJ Kang, and H Kaufmann (2022) mTOR inhibition with sirolimus in multiple system atrophy: a randomized, double-blind, placebo-controlled futility trial and 1-year biomarker longitudinal analysis. Mov. Disord., 37: 778-789.
- H Shahpasand-Kroner, I Siddique, R Malik, G Linares, MI Ivanova, J Ichida, T Weil, J Münch, E Sanchez-Garcia, F-G Klärner, T Schrader, and G Bitan (2023) Molecular tweezers – supramolecular hosts with broad-spectrum biological applications. Pharmacol. Rev., 75: 263-308.
- S Dutta, S Hornung, HB Taha, K Biggs, I Siddique, LM Chamoun, H Shahpasand-Kroner, C Lantz, M Herrera-Vaquero, N Stefanova, JA Loo, and G Bitan (2023) Development of a novel electrochemiluminescence ELISA for quantification of α-synuclein phosphorylated at Ser129 in biological samples. ACS Chem Neurosci., 14: 1238-1248.
- M Giaccio, A Monaco, L Galiano, A Parente, L Borzacchiello, R Rubino, F-G Klärner, D Killa, C Perna, P Piccolo, X Pan, M Khijniak, I Siddique, T Schrader, AV Pshezhetsky, CN Sorrentino, G Bitan, and A Fraldi (2024) Anti-amyloid treatment is broadly effective and synergizes with gene therapy in neuronopathic MPS. Mol. Ther., 32: 4108-4121.
- I Siddique, J Di, D Markovic, CK Williams, HV Vinters, and G Bitan (2021) Exophers are components of mammalian cell biology in health and disease. bioRxiv, DOI: https://doi.org/10.1101/2021.12.06.471479.